Hemoglobin E syndromes in Pakistani population

Hemoglobin E syndromes in Pakistani population

BACKGROUND Hemoglobin E is an important hemoglobin variant with a worldwide distribution. A number of hemoglobinopathies have been reported from Pakistan. However a comprehensive description of hemoglobin E syndromes for the country was never made. This study aimed to describe various hemoglobin E disorders based on hematological parameters and chromatography. The sub-aim was to characterize he...

Hemoglobin e syndromes.

Hemoglobin (Hb) E is one of the world's most common and important mutations. It results in a heterogeneous group of disorders whose phenotype range from asymptomatic to severe. Hb E trait and Hb EE are mild disorders. The combination of Hb E and Hb S (Hb SE) results in a sickle cell disease syndrome similar to sickle beta(+) thalassemia. It is important to distinguish Hb E disorders diagnostica...

The hemoglobin E syndromes. I. Hemoglobin E in Eti-Turks.

With the technical assistance of Kaniil Tanrikulu H EMOGLOBIN E has been found with variable frequency among peopies of southeast Asia, such as the Thais,’ ’” the Burmese,2 the Malasians,3 the Indonesians,4 ”4’ the Bengalis,5#{176}’5” and Filipinos,6 and Vcddas of Ceylon.T37h Sporadic cases have been encountered in other countries.6’8 In 1955 an example of the hemoglobin E trait was discovered ...

Genetic Polymorphism of CYP2C19 in Pakistani Population

CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

Prevalence of Gynaecomastia in Male Pakistani Population